In this edition of the game "Guess Who", players choose a Secret Character from the stack of Mystery Cards and place their Character cards in front of them. Then, each player asks a question and receives a Yes or No answer from their opponent.

The answers help to guess who the Character on their opponent's Mystery Card is. When a player thinks they have figured out who the Character on their opponent's Mystery Card is, they state their guess. If they guess correctly, they win. If they guess wrong, they lose!