The plague has spread throughout the city of Bristol. You roam the streets with your cart, trying to organize a desperate escape to the countryside for yourself and a few others, to escape this situation. You are certain that everyone in your cart is healthy, so you hurry to be the first to start. However, some people in your cart may already be carriers of the disease. They carefully hide the initial symptoms and try to enjoy their days as if nothing is wrong. So, you must make sure that you don't bring someone already sick with you, as you will also get infected and your journey will be meaningless.

Bristol 1350 is a standalone game, the fourth in the Dark Cities series, following Salem 1692, Tortuga 1667, and Deadwood 1876.