Professor Robert Langdon receives a late-night phone call while in France for business: the curator of the Louvre has been brutally murdered inside the museum. Next to the body, the police have found a series of puzzles and they need Langdon's help to solve them.
As Langdon and a French cryptographer, Sophie Neveu, try to unravel the mystery, they come across some clues that lead them to the works of the famous artist Leonardo da Vinci. As the pieces of the puzzle fall into place, they are confronted with an incredible historical truth that is in danger of being lost forever...