Mel, a renowned heart surgeon, is well-known for being a stoic loner. She views her erotic flings with other women as a tool for pleasure rather than a show of affection. When she delivers bad news to patients' families, her cold nature can make her seem heartless. Then she meets Lynn, a beautiful and spirited cardiac patient who needs a new heart, but refuses a transplant. The two women meet with minimal expectations but soon become enthralled in a relationship that changes everything for them both.