The book is an updated manual that tracks the timeless evolution of the central issues that concern Economic Geography from early approaches to recent discussions, incorporating multiple (and interdisciplinary) considerations. Indicatively, it explores the spatial organization and the impacts of complex supranational production networks on small businesses and local economies, the impacts of Information and Communication Technologies on spatial organization, as well as the strategies for international establishment of International Companies in the services and retail sector. It critically comments on the central points of theoretical discussion and presents exemplary cases and specially designed case studies from the real world.