It is the last year of Miles and Niles at the Valley of the Hilarious Academy of Letters and Sciences, and the Terrible Two have one goal in mind: to pull off an epic prank. Something big, something clever, something that will leave a lasting legacy at their school - which should be a piece of cake for the two experts, especially now that their principal has become their arch-nemesis.

However, whatever plan they have in mind crumbles like a house of cards when they discover that the new school inspector is Bertrand Barkin, the principal's father and their sworn enemy. As the school inspector, Bertrand Barkin prioritizes his duties, with his first and foremost being to get revenge on the Terrible Two.

The finale of Miles and Niles' adventures will be hilarious and prove that in the end... he who laughs last, laughs best!