Thessaloniki 1347 AD: Pamphilos has faced the plague and survived. Haunted by the deadly disease, he meets Meluas and Aluel, two people who will radically change his life. And all this while death reigns in the Byzantine city, at the height of the Middle Ages and obscurantism.

Thessaloniki 2017 AD: The efforts of Alex and Scarlett to contain the spread of the disease are not bearing fruit. More and more countries are getting infected, while the global health system is collapsing. New obstacles, which they must overcome, come to light in their morbid daily life.

The dead are increasing. Survival is fading. No one is invulnerable.

The "Fourth Horseman" reaches an unexpected end, in two worlds walking into chaos; science is unable to find the solution, while religion and so-called "national security" become tools that undermine the foundations of modern society, pushing the heroes to question what is truly worth it in the end.