Winter 1347 AD: A deadly enemy is born on the steppes of Kyrgyzstan. Pampilos, a Byzantine warrior, is at the center of the destruction. A besieged city is burning to the ground, and the survivors, struggling for their survival, seek refuge in Constantinople, carrying something that will change the course of history.

Winter 2017 AD: In a construction site of the Thessaloniki metro, a worker discovers an underground crypt. Unintentionally, he will awaken the greatest biological enemy in history. The pandemic spreads rapidly worldwide, and Alex, an epidemiologist at KEELPNO, faces superior forces, with Scarlet, a delegate of the World Health Organization, by his side.

Everyday people are confronted with the threat in a deadly game. The rules are timeless. Survival is the only way.

The first part of the duology "The Fourth Horseman" deals with a deadly scenario in the modern world of overpopulation and instant air connectivity to every corner of the planet, where the boundaries between fiction and reality seem thinner than ever before.